We also herein showed that serum levels of TARC, IL-22, and IgE and the degree of epidermal thickening positively correlated with the clinical scores VAS (degree of itching), and that serum levels of TARC and IL-22 and the degree of epidermal thickening were positively correlated with clinical scores of EASI (degree of dermatitis). Here, IGHE is linked to skin disorder.