The detection of intracellular TrkA and phosphorylated TrkA isoform immunoreactivity in CMMs in the present study extends previous reports that enhanced TrkA expression and intracellular phosphorylated TrkA immunoreactivity are associated with poor prognosis in CMM [9,10], but contrasts with a recent report that TrkA immunoreactivity is not associated with CMM progression [13]. This evidence concerns the gene NTRK1 and familial congenital mirror movements.