We also show that reductive stress activates the UPR and promotes TrkAIII mRNA expression in BRAF(V600E)-mutated A375 melanoma cells and, in transient TrkAIII A375 transfectants, promotes TrkAIII and Akt phosphorylation, resulting in increased resistance to reductive-stress-induced death, which is prevented by the Trk inhibitors lestaurtinib and entrectinib. This evidence concerns the gene NTRK1 and melanoma.