This difference underpins TrkAIII oncogenic activity in NB cells, which is characterised by pro-survival (B-cell lymphoma extra-large, Bcl-xL, myeloid cell differentiation protein-1, Mcl-1 and superoxide dismutase-2, SOD-2) and pro-angiogenic (vascular endothelial cell growth factor, VEGF, matrix metallpproteinase-9, MMP-9) gene expression, centrosome amplification and stress-regulated metabolic adaptation, within a de-differentiated cancer-stem-cell-like context [14,15,22,23]. Here, SOD2 is linked to cancer.