Numerous proteins migrate to the nucleus in cancer to exert their moonlighting function as a transcription factor or that are involved in repair, including, among others: Hexokinase-2 [54]; L-Xylulose Reductase (XR) [55]; 60S Ribosomal Protein L11 [56]; Pyruvate Kinase PKM2 [57], Protein-Glutamine γ-Glutamyltransferase 2 (TG2) [58]; Growth/Differentiation Factor 15 (GDF-15) [59]; TGF-β Receptor type-1 (TGFR1) [60]; Epidermal Growth Factor Receptor (EGFR) [61]; β-Catenin [62]; or E-Cadherin [63]. This evidence concerns the gene HK2 and cancer.