Some canonical functions are however cause by excess (c-e), such as the excess of Telomerase Component 1 (TEP1), the Lactate Dehydrogenase (LDH-A) excess, and MDM2 excess in cancer [25,26,27]; Hexokinase I in Hyperinsulinism [28]; the HSP90α excess in Huntington disease [29]; or the Nitric Oxide Synthase excess in Parkinson [30]. The gene discussed is MDM2; the disease is juvenile Huntington disease.