MIA and chondrosarcoma: To confirm MMP13 regulation by MIA/CD-RAP, we performed an siPOOL-mediated knockdown of MIA/CD-RAP in the human chondrosarcoma cell-line SW1353 (Figure 1A,B) and revealed a significant downregulation of MMP13 mRNA after 72 h of siMIA transfection (Figure 1C).