ERN1 and Alzheimer disease: In particular, the expression of genes coding for the enzymes BACE1, IRE1 (i.e., Ern1), IDE and Nicastrin, which control Aβ metabolism, was altered in the hippocampus of F1HFD 3xTg-AD mice compared to controls (fold change: +4.76 for Bace1, p = 0.0158; +4.57 for Ern1, p = 0.0059; −4.95 for Ide, p = 0.0009; −5.16 for Nicastrin, p = 0.0235; n = 4; Figure 2A).