The AD brain is characterized by the dysregulation of multiple pathways causing neuroinflammation, oxidative stress, mitochondrial and protein dyshomeostasis, which appear as an alteration of synaptic functions and the development of molecular hallmarks including deposition of both amyloid-β-protein (Aβ) and phosphorylated microtubule-associated protein Tau (i.e., neurofibrillary tangles, NFTs) [2,3]. Here, MAPT is linked to Alzheimer disease.