We found elevated binding of both NF-kB and STAT3, and higher levels of H3K9ac on the regulatory sequences of Bace1 in the hippocampi of F1HFD 3xTg-AD mice (P1: +166.1% for NF-kB, p = 2.63 × 10−5, +146.7% for STAT3, p = 3.34 × 10−5, +75.2% for H3K9ac, p = 1.19 × 10−5; P2: +87.4% for H3K9ac, p = 0.0056; n = 6; Figure 4A). This evidence concerns the gene STAT3 and Alzheimer disease.