To investigate the role of NF-kB, STAT3 and epigenetic modifications in the HFD-dependent alteration of AD-related gene expression, we analyzed the levels of both transcription factors and transcriptional activity marker histone H3 lysine 9 acetylation (H3K9ac) on the promoters of Bace1 and Ern1 genes. This evidence concerns the gene STAT3 and Alzheimer disease.