No binding was detected for transcription factor NF-kB on the promoter of Ide, whereas higher recruitment occurred on the promoter of Nicastrin in the hippocampi of mice derived from overfed mothers (+310.2% for F1HFD 3xTg-AD mice, p = 0.0003; n = 6; Figure 4B). Here, NFKB1 is linked to Alzheimer disease.