Immunoblot analysis detected hyperphosphorylation of both NF-kB and STAT3 in the hippocampi of F1HFD 3xTg-AD mice (pNF-kBSer536: +92.1%, p = 0.0001; pSTAT3Tyr705: +96.5%, p = 2.53 × 10−7; n = 6; Figure 3B). The gene discussed is STAT3; the disease is Alzheimer disease.