The phosphorylation of Ser536 by PKD3 as well as that of Ser276 by PKD2 are both critical for the transactivation of NF-κB and the expression of the urokinase-type plasminogen activator (uPA), which is in turn, indispensable for prostate cancer cell invasion [15]. The gene discussed is PLAU; the disease is Familial prostate cancer.