Moreover, TREM2 also has phagocytosis, a function that has been shown to be instrumental in many degenerative diseases associated with neuroinflammation, such as Alzheimer’s disease (AD), MS, Parkinson’s disease (PD), etc. A number of studies have reported that the expression of TREM2 is significantly decreased in LPS-induced sepsis models [15,16,17]. Here, TREM2 is linked to Alzheimer disease.