Higher values in the SF-36 Physical Functioning dimension were consistently reported by SMA type III/IV patients (p < 0.001; n = 33), patients with ≥4 SMN2 copies (p = 0.006; n = 27), and patients without NIV (p = 0.004; n = 33), wheelchair use (p < 0.001; n = 33), or scoliosis (p < 0.001; n = 32) (Figure 1). The gene discussed is SMN2; the disease is scoliosis.