G. frondosa polysaccharides promoted lipid metabolism and homeostasis by activating Decay Accelerating Factor16/Forkhead Box O and SKN-1/nuclear factor erythroid 2-related factor 2 (Nrf2) signal pathways or inhibiting Toll-like receptor 4 (TLR4)/NF-κB signal transduction, all of which are associated with inflammation and insulin resistance [116,136]. Here, NFE2L2 is linked to Insulin resistance.