The effects of Agrocybe cylindracea polysaccharide on adipose accumulation and weight loss in HFD-induced mice have been reported, and it was found that Desulfovibrio was decreased and Parabacteroides was increased, which markedly reduced the levels of obesity-related tumor necrosis factor α (TNF-α) and interleukin-6 (IL-6) [114]. This evidence concerns the gene TNF and obesity due to melanocortin 4 receptor deficiency.