AKT1 and Disorder of lipid metabolism: Using 55% ethanol extraction for G. frondose inhibited the liver stearoyl-Coenzyme A (CoA) desaturase 1, sterol regulatory element-binding transcription factor-1c and acetyl CoA carboxylase signaling pathways by increasing the levels of AKT1, glucokinase, AMPK-α and cholesterol 7-α hydroxylase, thereby improving glucose and lipid metabolism disorders [112].