The hub genes calculated by Cytoscape software are MNDA (score 320), CYBB (score 314), CD86 (score 312), FCGR2C (score 242), NCF2 (score 240), LCP2 (score 182), TLR8 (score 148), HLA-DRA (score 54), LCP1 (score 30), and PTPN22 (score 8), which are considered to be associated with obesity-related AF. The gene discussed is TLR8; the disease is obesity due to melanocortin 4 receptor deficiency.