Furthermore, PTEN of tumor EVs appeared to regulate the PI3K/AKT pathway, leading to AKT dephosphorylation and increasing the expression of pro-apoptotic BAX and decreasing antiapoptotic Bcl-2, Bcl-xL, and MCL-1 (myeloid leukemia cell differentiation protein) in activated killer T cells [203,204,205]. The gene discussed is AKT1; the disease is neoplasm.