NT5E and head and neck squamous cell carcinoma: Higher CD73-high TAMs infiltration levels in the HNSCC microenvironment were correlated with poorer prognoses, while CD73+ sEVs activated the NF-κB pathway in TAMs, thereby inhibiting immune function by increasing cytokines secretion such as IL-6, IL-10, TNF-α, and TGF-β1.