In contrast, OPMD keratinocytes derived from lesions that did not progress to OSCC (D34, D4, D9, D38) showed only focal SCNAs involving FHIT (2/4 cultures), CSMD1 (3/4 cultures) and gains of chromosome 20 (3/4 cultures). This evidence concerns the gene CSMD1 and oculopharyngeal muscular dystrophy.