A more recent study by Brann’s laboratory generated a glial fibrillary acidic protein promoter-driven aromatase-knockout (GFAP-ARO-KO) mouse model to deplete astrocyte-derived E2 in the brain, and the animals showed elevated neuronal damage, microglial activation, and cognitive impairment following GCI [18]. This evidence concerns the gene CYP19A1 and Cognitive impairment.