Previous studies have also demonstrated that folic acid and folate receptors (FOLRs) play an important role in the downregulation of homocysteine, a risk factor of Alzheimer’s disease [30], and, together with our results, we suspect that the decreased FOLR1 protein levels in KDM6B variants might be due to decreased H3K27Ac which might compromise FOLR1 transcription (Supplementary Figure S2). Here, FOLR1 is linked to Alzheimer disease.