FOLR1 and early-onset autosomal dominant Alzheimer disease: Previous studies have also demonstrated that folic acid and folate receptors (FOLRs) play an important role in the downregulation of homocysteine, a risk factor of Alzheimer’s disease [30], and, together with our results, we suspect that the decreased FOLR1 protein levels in KDM6B variants might be due to decreased H3K27Ac which might compromise FOLR1 transcription (Supplementary Figure S2).