circRNA can also associate with RNA-binding proteins to modulate the cell cycle, for example, in atherosclerosis, where circANRIL binds to Pescadillo ribosomal biogenesis factor 1 (PES1), causing the inhibition of ribosome maturation, which leads to nucleolar stress and p53 expression, with a subsequent decrease in proliferation and an increase in apoptosis [160]. Here, PES1 is linked to atherosclerosis.