IL6 and COVID-19: Similarly, activation of COX2 and HIF-1α in COVID-19 has been shown to upregulate the antiapoptotic antiproliferative microenvironment (BCL2, BNIP3) [43] and M1 immune system {nuclear factor kappa B (NFKB) [44], Egl-9 family hypoxia inducible factor 3 (EGLN3) [45], CXCL8 [46], TNF-α [47], and IL-6 [48]}.