In recent years, more attention has been paid to tumor-associated macrophages (TAMs), a distinct macrophage population that expresses M1 products such as interleukin-8 (CXCL8), tumor necrosis factor-alpha (TNF-α), and interleukin-6 (IL-6) as well as M2 compounds such as matrix metalloproteinases (MMPs), interleukin-10 (IL-10), CC chemokine ligand 17 (CCL17) and CC chemokine ligand 22 (CCL22). This evidence concerns the gene TNF and neoplasm.