NR0B1 and myocardial ischemia: For this experiment, the RNA of the gene Dax1 was degraded, and its protein amount was severely reduced by a short hairpin (sh) RNA targeted to Dax-1. The aim was to increase the production of 17β-estradiol, which has neuroprotective properties and beneficial effects on recovery in stem cell therapy after cerebral or myocardial ischemia.