The ability of OM-MSCs to secrete Pigment epithelium-derived factor (PEDF) was found to be crucial in the restoration of phosphatidylinositol-3-kinase/serin-threonin kinase 1/mammalian target of rapamycin (PI3K/Akt/mTOR) pathway, which resulted in being impaired in ischemia/reperfusion injury, and partially recovered when OM-MSCs were used. This evidence concerns the gene MTOR and ocular melanoma.