PTGS2 and infection: A recent study by Chen et al. showed that inhibition of COX-2/PGE2 signaling via ibuprofen and meloxicam, a moderately selective COX-2 inhibitor, had no effect on ACE2 expression, viral entry, or viral replication [182], thereby disproving the concerns that ibuprofen might lead to more severe infections via upregulation of ACE2.