The lemon nanovesicles suppress CML tumor growth in vivo by specifically reaching the tumor site; they then activate TRAIL-mediated apoptotic cell processes and inhibit the secretion of VEGF-A (vascular endothelial growth factor A), IL-6 (interleukin-6), and IL-8 (interleukin-8) to suppress angiogenesis [71]. This evidence concerns the gene VEGFA and chronic myelogenous leukemia, BCR-ABL1 positive.