INS and diabetes mellitus: Other side effects of diabetes have also been studied with approaches using silica nanoparticles, including encapsulated Echinacea purpurea ethanol extract [126], and triterpenoids from Petri dish-cultured Antrodia cinnamomea [127] for modulation of diabetes-induced reproductive dysfunction, cerium(III) chloride-loaded MSNs for alleviation of diabetic cataract development and progression [128], and resveratrol-loaded MSNs in immunoregulation and insulin resistance alleviation for diabetic periodontitis therapy [129].