AKT1 and human papilloma virus infection: The major pathways which enriched more proteins were: Focal adhesion (30.5%), ECM-receptor interaction (28.0%), Human papillomavirus infection (28.0%), PI3K-Akt signaling pathway (26.8%), Complement and coagulation cascades (19.5%) and Proteoglycans in cancer (14.6%) (Figure 2).