INS and type 2 diabetes mellitus: It is well known that impaired glucose metabolism, insulin resistance, inflammation, oxidative stress, amyloid accumulation, advanced glycosylation end products accrual, and mitochondrial dysfunction are biological events that occur in both T2D and AD (reviewed in [9,19]), such that AD has been recently designated as “type 3 diabetes” [20] or “diabetes of the brain” [21].