This discovery suggests that C2 ceramide is implied in the development of insulin resistance by keeping PKB in an inactive state as well as, probably, through the involvement of the principal phosphatase that dephosphorylates the serine/threonine protein kinase in adipocytes [108]: protein phosphatase 2A (PP2A), which is okadaic-acid-sensitive [107]; this hypothesis was confirmed by the suppression of the sphingolipid’s effects through the expression of a PP2A inhibitor: the SV40 small T antigen [103]. The gene discussed is PTPA; the disease is Insulin resistance.