In line with this elegant study and in a translational approach, we identified S1P as a powerful biomarker associated with high blood pressure, since the increase in circulating S1P (alongside soluble NADPH oxidase 2-derived (NOX2-derived) peptide) was more pronounced in uncontrolled hypertensive patients and linearly correlated with each other in the entire hypertensive cohort [72]. The gene discussed is CYBB; the disease is hypertensive disorder.