MCAM and central nervous system cancer: In addition to these models, orthotopic xenograft mice models were used to demonstrate the capacity of [64Cu]Cu-NOTA-YY146 to penetrate the disrupted BBB and efficaciously target CD146 within brain tumors, demonstrating that expression levels of CD146 can be scrutinized non-invasively in high-grade gliomas with PET imaging for potential patient selection and stratification for targeted therapies [80].