TFRC and proteostasis deficiencies: Furthermore, a recent study with variants of the rat TfR antibody, OX26, chemically conjugated to F(ab ́)2 fragments of Bapi has demonstrated that the TfR-mediated transport of an immunoPET radioligand enables sensitive imaging of brain Aβ pathology in a rat model of AD (Figure 2C) [32].In addition to beta-amyloidopathy, another proteinopathy, α-synuclein (αSYN) deposition, has been studied by immunoPET.