Sixty-two percent of all cancer-inducing p53 mutations (eighty-two percent for HGSOC) occur as missense mutations in the DBD (R175, Y220, G245, R248, R249, R273, or R282), resulting in the eradication of DNA-binding functions, either directly or indirectly; see Figure 1 (blue lines) [41,45,47,48]. The gene discussed is TP53; the disease is cancer.