NR4A1 and breast cancer: The most common histological type of breast cancer is invasive ductal carcinoma (IDC), which accounts for 70–75% of total incidences [4,5], As the dominant category of breast cancer [6], IDC expresses lower hormone receptors than invasive lobular carcinoma(ILC), while exhibiting advanced blood vessel infiltration capacity [5] and a high percentage of the development of lung metastasis [7,8].