CD8+ T cells downregulate the expression of SLC3A2 and SLC7A11, two subunits of the glutamate–cystine reverse transport system Xc-, by releasing IFNγ, which in turn impairs cystine uptake by tumor cells, promoting tumor cell lipid peroxidation and the onset of ferroptosis [22]. This evidence concerns the gene SLC3A2 and neoplasm.