TUM1 deficiency has been implicated to be responsible for a rare inheritable disorder known as mercaptolactate-cysteine disulfiduria (MCDU), which is associated with mental disorder [19,84] since, in TUM1 KO cells, sulfite oxidase activity is reduced; the mental disorder of TUM1 deficiency might be related to the symptoms of sulfite oxidase deficiency which is also characterized by neurological disorders [85]. Here, MPST is linked to nervous system disorder.