Although, to the best of our knowledge, this is the first in vitro study describing PS-MPs effects in human colorectal carcinoma intestinal cell line HRT-18 and providing further information about IL-8 modulated expression and release after PS-MPs treatment, further studies that are more representative of natural conditions will be needed to shed further light on microplastic toxicity. This evidence concerns the gene CXCL8 and colorectal carcinoma.