PAGE4 and Familial prostate cancer: Given that CLK2 and PAGE4 are expressed only in androgen-dependent prostate cancer cells whereas HIPK1 is expressed in all prostate cancer cells (both androgen-dependent and -independent), these phosphorylation states that result in the expanded and contracted conformational ensembles were correlated with androgen sensitivity in prostate cancer [83,144,185,186,187,188,189].