The use of either the JAK2 inhibitor JSI-124 or small RNA interference of JAK2 inhibited the transition of pulmonary artery endothelial cells to fibroblasts in vitro, and in vivo models also confirmed that JAI-124 attenuated pulmonary fibrosis-induced pulmonary artery remodeling [136]. This evidence concerns the gene JAK2 and pulmonary fibrosis.