Finally, the glomerular filtration rate in patients with early and progressive diabetic nephropathy was negatively correlated with JAK1, JAK2, JAK3, and STAT1 mRNA expression in the tubulointerstitial compartment, while there was no correlation between glomerular filtration rate and JAK/STAT activation in the glomeruli of the kidney [99]. Here, JAK3 is linked to diabetic kidney disease.