CTSD and neoplasm: This analysis identified 13 key biomarkers with prognostic relevance for tumor recurrence/systemic disease within 4 years of tumor excision, among them S100A8 (S100 calcium binding protein A8), S100A9 (S100 calcium binding protein A9), HSPB1 (Heat Shock Protein Family B (Small) Member 1), IL1RN (Interleukin 1 Receptor Antagonist), PTGES (Prostaglandin E Synthase), and CTSD (Cathepsin D) (Figure 3C,D).