Anti-immunoglobulin E (IgE) antibodies and the suppression of the interleukin (IL)-5 signaling pathway improved the endoscopic findings and chronic digestive symptoms of non-EoE EGID; nevertheless, acute and subacute symptoms had occurred due to ingestion of the causative foods, meaning that the improvements were not clinically sufficient, and suppression of the IL-4/IL-13 signaling pathways led to the acquisition of tolerance to the causative foods. The gene discussed is IGHE; the disease is eosinophilic esophagitis.