Given the breadth of XPO1 cargo molecules and the potentially pleotropic effects of selinexor on cellular function in NHL, Seymour et al. examined whether inhibition of nuclear export via selinexor could restore the balance of these pathways and improve the response rates in the context of a selinexor R-CHOP combination [43]. Here, XPO1 is linked to non-Hodgkin lymphoma.