Other researchers had focused on the inhibitory effect of tumor necrosis factor-α (TNF-α)-induced VCAM1 mRNA expression by HDL, known as the HDL anti-inflammatory function [56], and noted that anti-inflammatory capacity was inversely associated with CHD risk in the PREVEND (Prevention of Renal and Vascular End Stage Disease) study [42] (Table 1). The gene discussed is TNF; the disease is coronary artery disorder.