IGF2 and adrenal cortex carcinoma: In addition, previous studies have identified multiple genes and pathways as potential prognostic biomarkers for patients with ACC, such as the driver genes IGF2, TP53, CTNNB1 [6], NR5A1, and FSCN1 [59,60], and the p53-RB and WNT-β-catenin pathways [56].