CYP46A1 and infection: Since the central nervous system enzyme cytochrome P450 46A1 (CYP46A1) can be activated in small doses by the reverse transcriptase inhibitor, which may aid the brain in metabolizing increasing levels of cholesterol during Alzheimer’s [55] Plus, for the potential treatment of the Zika virus (ZIKV), the authors used Vero cells to assay the ability of efavirenz and other compounds to inhibit ZIKV 2 h after infection.