Our present results, together with those we recently published [5], strongly suggest that if GAA really causes epilepsy in GAMT-deficient patients it does not do so by increasing the excitability of neuronal networks, even if the possibility remains that it may cause epilepsy in such patients by altering the development of neuronal connections, as Hanna-El-Daher et al. have shown [6]. This evidence concerns the gene GAMT and epilepsy.