(Figure 5E–G) This hypothesis is supported by the increased expression of protein homeostasis related genes and the stress maker NPPA specific to the LAMP2 KO cells after MM treatment, (Figure 5H, Supplemental Figure S3E–H) although other mitochondrial and sarcomere proteins remained unchanged (Supplemental Figure S3I–L). This evidence concerns the gene LAMP2 and Miyoshi myopathy.