Furthermore, Memarzadeh and colleagues found that enhanced mesenchymal expression of FGF10 causes multifocal prostate-intraepithelial neoplasia or adenocarcinoma in mice attributable to FGF10 paracrine signaling, and this phenotype was rescued by attenuating fibroblast growth factor receptor-1 or -2 (FGFR1 or FGFR2) signaling in prostate epithelial cells using dominant-negative FGFR1/2 constructs [100]. The gene discussed is FGFR1; the disease is prostate intraepithelial neoplasia.