Given that EMT is linked to prostate cancer cell dissemination and metastatic spread [117,118,119] and that EMT is associated with the expression of αSMA, FSP1, vimentin and desmin that are commonly detected in CAFs [120], it stands to reason that some of these cells, having adopted a mesenchymal phenotype, could differentiate into CAFs. The gene discussed is DES; the disease is prostate cancer.