QRTPCR analysis of FACS sorted human prostate cancer CD90+ CAFs revealed a significant upregulation of VEGFA mRNA expression relative to normal fibroblasts, while Tag profiling of human prostate cancer CAFs reported an increase in VEGFD expression in CD90-negative CAFs [77,103], indicating that different subpopulations of CAFs may induce angiogenesis via upregulation of distinct growth factors. This evidence concerns the gene VEGFD and Familial prostate cancer.