Increased ECM thickness is also reported to increase the activity of focal adhesion kinase (FAK), Rac, extracellular signal-regulated kinase (ERK) and yes-associated protein/transcription co-activator with PDZ-binding motif (YAP/TAZ) signaling cascades, which facilitate tumor growth, progression and invasion [186,187,188]. This evidence concerns the gene AKT1 and neoplasm.