Numerous cells within the TME express AR, including CAFs, fibroblasts, endothelial cells, immune cells and disseminated prostate cancer cells [261], and AR signaling between the stromal and epithelial compartments is integral to normal prostate development and for the maintenance of normal adult prostate tissue homeostasis (as detailed in Section 1.1.1), tumorigenesis and CRPC growth [13,14,15,19,20,21,262]. Here, AR is linked to Familial prostate cancer.