TGFB1 and Familial prostate cancer: TGFβ is a well-studied driver of fibroblast-to-myofibroblast differentiation, and is commonly overexpressed by prostate cancer cells, resulting in constitutive activation of the myofibroblast phenotype through apoptosis evasion and continuous proliferation to form a heterogenous CAF subpopulation [13,48,90,91].