For instance, PI3K hyperactivation in a transgenic mouse model of prostate cancer that harbors an activating mutation in PIK3CA (that encodes the PI3K catalytic subunit p110α) has also been shown to exhibit profound stromal remodeling characterized by increased collagen deposition caused by expansion of TGFβ-activated CAFs [134]. The gene discussed is TGFB1; the disease is Familial prostate cancer.