The FGF-FGFR signaling axis has many downstream effector cascades, including RAS/MAPK, PI3K/AKT/mTOR and JAK/STAT signaling pathways [213,214], thus providing potential mechanisms whereby CAF-mediated activation of FGF signaling in prostate cancer cells could promote tumor growth. This evidence concerns the gene AKT1 and Familial prostate cancer.