Additionally, co-expression of CD90 and CXCL12 in primary CAFs isolated from prostate tumors with Gleason scores of 3 + 4 or 4 + 4 positively correlates with induction of TGFβ-dependent pro-tumorigenic CXCR4 signaling in human BPH1 cells in co-culture assays or with conditioned media (CM) from CD90High CAFs, although the magnitude of the TGFβ-dependency remains to established [77]. The gene discussed is THY1; the disease is prostate neoplasm.