Although the true extent of direct/indirect TGFβ-mediated CAF activation remains to be elucidated, recent evidence suggests that TGFβ paracrine signaling via TGFβ-containing EVs secreted by prostate cancer cells may mediate fibroblast differentiation into myofibroblasts and/or CAFs [142]. The gene discussed is TGFB1; the disease is prostate carcinoma.