GSKJ4, an inhibitor of KDM6A (UTX) and KDM6B (JMJD3) enzymes, induced apoptosis and cell-cycle arrest in Kasumi-1 cells, decreased proliferation of U-937 and K-562 cells, and attenuated disease progression in a human AML xenograft mouse model [171,172]. This evidence concerns the gene KDM6B and acute myeloid leukemia.