Inhibition of BRG1 resolved differentiation blockade in fusion positive rhabdomyosarcoma cell lines [213], while depletion of CHD4, a coregulator of the oncogenic PAX3-FOXO1 transcription factor, resulted in reduced viability of fusion-positive but not of fusion-negative rhabdomyosarcoma in vitro [214]. This evidence concerns the gene SMARCA4 and rhabdomyosarcoma.