Although tenovin-6-mediated SIRT1/2 inhibition hampered the growth of primary cells from children with ALL [106], and silencing of SIRT1 prolonged the lifespan in a mouse model of T-ALL [107], the growth of leukemic cells was promoted by SIRT1 inhibition and reduced by SIRT1 activation in two T-ALL cell lines carrying Notch mutations [108]. This evidence concerns the gene SIRT1 and acute lymphoblastic leukemia.