HIF1A and Familial prostate cancer: In the study of PC-3 and DU-145 prostate cancer cells, Thomas et al. [85] demonstrated that mitochondrial uncouplers, rottlerin and FCCP, tremendously reduced hypoxic and normoxic HIF-1 transcriptional activity; the process was partly mediated by a reduction in the levels of oxygen labile HIF-1α and HIF-2α proteins.