By analyzing the scRNA-seq data from 14 oocytes from seven healthy fertile women and 20 oocytes from nine patients with PCOS at the germinal vesicle (GV) stage, metaphase I stage, and metaphase II (MII) stage, Qi et al. discovered that some genes associated with mitochondrial function (for example, oxidative phosphorylation), such as COX6B1, COX8A, COX4l1, and NDUFB9 were prematurely activated at the GV stage of PCOS oocytes, whereas it occurs at the MII stage in healthy oocytes [109]. Here, COX8A is linked to polycystic ovary syndrome.