Based on current research, as some protein-coding RNAs targeted by miR-574-5p, such as QKI, PTPRU, SCAI, and FOXN3, are negative regulators of the Wnt/β-catenin pathway, miR-574-5p overexpression is capable of suppressing these proteins and activating β-catenin signaling in diverse cancer types, including SCLC, NSCLC, CRC, thyroid cancer, and cervical cancer. This evidence concerns the gene PTPRU and cancer.