A recent study has indicated that nicotinamide adenine dinucleotide-dependent sirtuin 3(SIRT3), a deacetylase sensitive to metabolic stimulation, facilitates autophagy deficiency and NLRP3-mediated atherosclerosis A recent study has indicated that nicotinamide adenine dinucleotide-dependent SIRT3, a deacetylase sensitive to metabolic stimulation, hinders autophagy deficiency and NLRP3-mediated atherosclerosis [140]. The gene discussed is NLRP3; the disease is atherosclerosis.