This could result from a mechanism where Ras GTPase-activating protein-binding protein 1 (G3BP1), a well-known oncoprotein, can specifically bind to m5C-modified H19 lncRNA, causing MYC accumulation to exert its oncogenic effect, closely linked to poor differentiation of HCC [35]. The gene discussed is MYC; the disease is hepatocellular carcinoma.