CALCA and bacterial infectious disease: Despite the high specificity of PCT for bacterial infections, its main limitation is that it could increase under certain circumstances of sterile inflammation, such as sterile pancreatitis [30], after major surgery [31], severe trauma [32], in cardiogenic shock [33], cardio-pulmonary resuscitation [34], rhabdomyolysis due to the ischemia-reperfusion injury and some malignancies [35], among others.