-Inhibition in vivo of the biofilm development of S. mutans in a Wistar rat model for dental caries.-Downregulation of genes located downstream to comA in MTCC 497 (except for immA and immB genes that were upregulated).-Decrease in inflammatory markers expression (TNF-α, CRP, IL-1 and IL-6) in liver and plasma samples. The gene discussed is TNF; the disease is dental caries.