According to the KEGG pathways analysis, potential targets of biosurfactants against listeriosis are significantly enriched in several important pathways, such as the ERBB signaling pathway, C-type lectin receptor signaling, Th17 cell differentiation and HIF-1 signaling pathway, etc. As described above, the ERBB signaling pathway plays an important role in listeriosis to invade bacteria in host cells. Here, CLEC4D is linked to listeriosis.