TNF and rheumatoid arthritis: Gene transcriptions suppressed by two flavones were significantly enriched in several pathways such as “cytokine-cytokine interaction”, “influenza A”, and “rheumatoid arthritis”, as shown in Figure 4c, d, but the inflammation-related pathways are the TNF and IL-17 pathways of 6,3 ́,4 ́-HOFL and the TNF, IL-17, and JAK-STAT pathway of 7,3 ́,4 ́-HOFL.