AGT and endothelial dysfunction: Our previous study verified that DHY attenuated transverse aortic constriction induced myocardial hypertrophy [4], alleviated cardiac fibroblasts proliferation and cardiomyocyte hypertrophy by angiotensin II (Ang II) stimulation [5,6], improved endothelial dysfunction in diabetic mice [7] and inhibited cellular cholesterol accumulation in oxidized low-density lipoprotein (ox-LDL)-stimulated macrophages [8].