The present data indicated that DHY improved cardiac dysfunction, ameliorated myocardial hypertrophy, fibrosis and injury and suppressed oxidative stress, inflammation and necroptosis via SIRT3 activation in STZ-induced diabetic mice, suggesting DHY may serve as a candidate agent to attenuate diabetic cardiomyopathy. The gene discussed is SIRT3; the disease is diabetic cardiomyopathy.